Lectures
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Lectures

Barrett’s Esophagus: Management of a Pre-Malignant and Malignant Disease of the Esophagus

K. Wayne Adkisson, M.D.
Barrett’s Esophagus: Management of a Pre-Malignant and Malignant Disease of the Esophagus
In this lecture we will define the condition of Barrett’s esophagus, briefly explore the epidemiology of Barrett’s esophagus and its relationship to adenocarcinoma. We will briefly talk about the role of surveillance, surveillance te…Continue Reading

Word Count: 3071

Hereditary Hemochromatosis

12-15-2009 Roger Orth, M.D.
Hereditary Hemochromatosis
Is Hemochromatosis a medical curiosity? Most common mendelian disorder USA affects .3-.8% 1:200 people 1.5 Million people Genetic Discordance Genotypic prevalence: 1:100 to 1:250 Phenotypic prevalence: 1:300 Highly underdiagnosed Like other spec…Continue Reading

Word Count: 857

Remicade

Roger Orth, M.D.
Remicade
Remicade represents a paradigm in treatment for Crohn’s disease. This new treatment is a very specific type of antibody – a chimeric monoclonal antibody. The antibody is made to attack one of the activating factors for inflammatory b…Continue Reading

Word Count: 591

The Origin of Public Health/Waterborne Diseases

Roger Orth, M.D.
The Origin of Public Health/Waterborne Diseases
2000 B.C. The very earliest civilizations have shown significant importance placed on public health in regards to public hygiene and subsequent sewage management. In the Indus Valley in Northern India, excavations show an early culture that had …Continue Reading

Word Count: 3545

The Human Genome Project/Molecular Applications to Medicine

Roger Orth, M.D.
The Human Genome Project/Molecular Applications to Medicine
“ The future ain’t what it used to be” Yogi Berra “ If you don’t know where you are going you may end up someplace else” Yogi Berra Any discussion of the human genome project must date back to the earliest sources, since the genome itself repres…Continue Reading

Word Count: 4218

Mad Cow Disease (Prion Disorders)

Roger Orth, M.D.
Mad Cow Disease (Prion Disorders)
I would like to take an opportunity to review some of the prion-related disorders now popularized in the lay press, which include the so-called mad cow disease. I have several reasons for studying these disorders. First, the prion disorders were…Continue Reading

Word Count: 3805

Why Louis Pasteur would have liked Nexium, reflections on chirality

Roger Orth, M.D.
Why Louis Pasteur would have liked Nexium, reflections on chirality
Reflections on Chirality There are several aspects that I would like to bring out in the title. I would like to include a series of historical vignettes about why Louis Pasteur and some of his counterparts in the mid 1800’s opened a way to…Continue Reading

Word Count: 5511

Genetics of Obesity – Bears do it–can we do it?

Roger Orth, M.D.
Genetics of Obesity – Bears do it–can we do it?
“Hibercare” for obesity.” My original plan was to limit this lecture to issues evolving related to genetics of obesity. Though I plan to discuss some of the aspects of genetics that are recently described, I would like to also …Continue Reading

Word Count: 4587

Prospects in Stem Cell Research – Reflections on Clones, Chimera, and Minotaur

Roger Orth, M.D.
Prospects in Stem Cell Research – Reflections on Clones, Chimera, and Minotaur
The future ain’t what it used to be. Signed, Yogi Berra If you don’t know where you are going, you may end up someplace else. Signed, Yogi Berra More than any other time in history, mankind faces a crossroads. One path leads to despa…Continue Reading

Word Count: 8804

Biology of Pancreatic Cancer

Roger Orth, M.D.
Biology of Pancreatic Cancer
The clinical problems of pancreatic cancer are significant indeed. At the time of presentation patients often have limited symptoms with a problem that involves a section of their body which up until presentation has seemed to work just fine. Pa…Continue Reading

Word Count: 4237

Pathophysiology and Management of Irritable Bowel Syndrome (IBS)

Roger Orth, M.D.
Pathophysiology and Management of Irritable Bowel Syndrome (IBS)
Management of irritable bowel syndrome has been difficult in deed since it is based on symptoms. There are no biological markers nor standard clinical tests to allow diagnosis of this disorder. Symptoms are often associated with abdominal discom…Continue Reading

Word Count: 1808

Role of Mitochondria in Aging and Cancer

Roger Orth, M.D.
Role of Mitochondria in Aging and Cancer
In this lecture, I will discuss some of the aspects of free radical theory as it involves aging and cancer. The initial aspects of the free radical theory were described by Harmon in 1956 – a physicist quite familiar with the effects of ra…Continue Reading

Word Count: 4880

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